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ARTIFICIAL INTELLIGENCE-INTEGRATED MECHANISTIC MODELING FOR RATIONAL DESIGN OF NANOPARTICLES TO IMPROVE ORGAN TARGETING AND SAFETY - PROJECT SUMMARY. NANOPARTICLES (NPS) HOLD GREAT PROMISE AS TARGETED DRUG DELIVERY SYSTE

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ARTIFICIAL INTELLIGENCE-INTEGRATED MECHANISTIC MODELING FOR RATIONAL DESIGN OF NANOPARTICLES TO IMPROVE ORGAN TARGETING AND SAFETY - PROJECT SUMMARY. NANOPARTICLES (NPS) HOLD GREAT PROMISE AS TARGETED DRUG DELIVERY SYSTEMS BUT TAILORING THEIR PHARMACOKINETICS (PK) TO SPECIFICALLY TARGET REGIONS OF INTEREST REMAINS A CHALLENGE. THIS LIMITS THE CLINICAL TRANSLATION OF NPS DUE TO POOR EFFICACY AND SAFETY CONCERNS ASSOCIATED WITH OFF-TARGET ACCUMULATION OF NP-BASED FORMULATIONS. DUE TO THE INTERACTIONS OF NPS WITH BIOLOGICAL COMPONENTS, DRIVEN BY THEIR STRUCTURAL PROPERTIES, CUSTOMIZING THE PHARMA

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