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Comparative Study of Anatomical and Learned Features in AI Models for Structural Brain MRI

arXiv · AI, language, vision and robotics · article · Sep 6, 2026 · UTC

In this work, we comprehensively evaluate three popular feature-extraction paradigms in AI-based neuroimaging modeling: (1) computation of anatomical surfaces and volumes, (2) supervised learning with convolutional neural networks (CNNs), and (3) unsupervised pretraining of vision transformer (ViT) foundation models, followed by supervised finetuning. Our study is based on 18 publicly available datasets containing 3D structural T1-weighted MRI scans from approximately 80,000 participants across seven distinct clinical tasks. We observe that a linear model based on anatomical features matches t

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