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Complementary Roles of Radiomics and Foundation Representations in Renal Cell Carcinoma Classification: A Comparative Study of 2D and 3D CT Encodings

arXiv · AI, language, vision and robotics · article · Sep 22, 2026 · UTC

Accurate preoperative subtype classification of renal cell carcinoma (RCC) from contrast-enhanced computed tomography remains clinically challenging. Radiomics provides structured tumour descriptors, whereas foundation representations offer transferable image features. However, it remains unclear whether radiomics still adds value beyond pretrained representations, and how 2D and 3D MedVAE encoders compare in this setting. We compared handcrafted radiomics, 2D MedVAE, 3D MedVAE, and their fusion for binary clear-cell RCC versus non-clear-cell RCC classification on KiTS23 under a unified prepro

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