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TopoFuse: Topology-Aware Tri-Planar Fusion for 3D Cryo-Electron Tomography Segmentation

arXiv · AI, language, vision and robotics · article · Aug 31, 2026 · UTC

Automated segmentation of cryo-electron tomograms routinely produces masks that are voxel-accurate but topologically broken: membranes fragment, organelles merge into one another, and enclosed cavities collapse. Existing topology-aware losses reduce these violations but cannot eliminate them, because topology is encouraged through gradient pressure rather than structurally enforced. We introduce TopoFuse, which reframes topology as a differentiable projection operator rather than a loss penalty. At each forward pass, the projection operator $\mathrm{Proj}_T$ (a PH-guided sparse edit) identifie

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