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Is Deformable Image Registration Ready for Brain Metastasis Reirradiation Dose Accumulation? A Longitudinal MRI Benchmark of Registration Accuracy

arXiv · AI, language, vision and robotics · article · Aug 27, 2026 · UTC

Dose accumulation is increasingly important in adaptive radiation therapy and reirradiation, but its clinical validity depends on the performance of deformable image registration (DIR). Reirradiation of brain metastases (BMs) with stereotactic radiosurgery (SRS) provides a controlled but clinically meaningful DIR test case: intra-subject brain deformation is usually limited after rigid alignment, yet recurrent lesions can undergo substantial local shape and volume changes that rigid registration cannot capture and can affect dose accumulation. We benchmarked a wide range of learning-based and

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