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Lesion-Gated Hybrid Synthesis for Virtual Contrast-Enhanced Breast MRI: A MAMA-SYNTH Challenge Solution

arXiv · AI, language, vision and robotics · article · Sep 18, 2026 · UTC

Purpose: Contrast-enhanced breast MRI depends on intravenous gadolinium-based contrast agents, motivating methods that synthesise post-contrast appearance from pre-contrast images alone. The MAMA-SYNTH Challenge (MICCAI 2026 Deep-Breath Workshop) evaluates such synthesis across four metric groups: image fidelity, tumour region of interest, downstream classification, and downstream segmentation. The four group ranks are averaged, so optimising a single objective is insufficient. Materials and Methods: We developed a lesion-gated hybrid synthesis pipeline. A lesion probability map, estimated fro

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