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Real-time Generalizable Heart Valve Mechanics for Clinical Disease Assessment via a Physics-Conditioned Neural Operator

arXiv · AI, language, vision and robotics · article · Sep 20, 2026 · UTC

Mitral regurgitation is the most common heart valve disorder worldwide, affecting over 2% of the global population, rising to at least 10% in adults over 75, and causing approximately 15% of valvular heart disease-related deaths. Yet only a minority of patients with severe disease undergo corrective surgery. Rapid assessment of valve mechanics could enable earlier, more precise intervention, but traditional finite element simulations remain too slow for clinical timelines and parameter sweeps. We introduce the Physics-Conditioned Neural Operator (PCNO), a transformer-based surrogate that predi

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