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Exemplar: Classical Priors Complement Frozen Features for Few-Shot Microscopy Segmentation at Native Resolution

arXiv · AI, language, vision and robotics · article · Sep 2, 2026 · UTC

Segmenting a new biomedical dataset usually means a domain-specific model trained on substantial annotation, or a foundation model steered at inference time. We present Exemplar, a few-shot segmenter that fuses a frozen DINOv3 backbone with a fixed bank of classical native-resolution filter responses in one lightweight head, fitted from the support masks alone. In the few-mask, native-resolution regime, classical priors and frozen self-supervised features are complementary: fused in one head, a single fixed configuration spans eleven biomedical imaging datasets. Under the same head, the classi

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