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PANDA - Prototype-Anchored Alignment for Partially Unpaired Multimodal Learning, with Applications to Alzheimers MRI and TCGA Pathology

arXiv · AI, language, vision and robotics · article · Aug 26, 2026 · UTC

Multimodal medical prediction often faces incomplete pairing: auxiliary modalities with complementary signal are available for only a subset of subjects (or none) and cannot be assumed at deployment. We introduce PANDA (Prototype Anchored Data Alignment), a two-stage framework that transfers auxiliary information to a primary-modality model without auxiliary inputs at inference. Stage 1 learns a shared embedding from the paired subset and estimates class prototypes from auxiliary modalities; Stage 2 trains the primary encoder on all subjects using cross-entropy plus alignment to the frozen pro

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